People inspect the damage at a site hit overnight by an air strike in the rebel-held area of Seif al-Dawla neighbourhood of Aleppo, Syria, September 30, 2016. REUTERS/Abdalrhman Ismail
MOSCOW: "Direct agression" by the United States towards the Syrian government and armed forces would lead to "frightening, tectonic shifts" in the Middle East, RIA news agency cited Russian Foreign Ministry spokeswoman Maria Zakharov as saying on Saturday.
Russia and the United States back opposing sides in the Syrian conflict.
A U.S.-Russian brokered ceasefire in Syria recently fell apart, and Russian war planes on Saturday struck rebel-held areas north of the Syrian city of Aleppo.